Menopause is a Critical Factor in Determining Failure of Antiviral Therapy in Women With Chronic Hepatitis C
Status:
Completed
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
Menopause represents a critical period in a woman's life as the hormonal changes and the
failing ovarian function not only determine relevant modifications in the reproductive
function but also in many other conditions and organs that apparently are scarcely linked
with hormones. The PI's centre has among its main goals the treatment of chronic liver
disease; in the last years, a increasing interest in gender-related issues has grown.
Goal of this study is to verify the impact of menopause on response to antiviral therapy for
CHC and in determining more severe fibrosis in comparison with age-matched men. To achieve
this goal a database of all the PEG IFN/Ribavirin patients treated in the GI Unit of the
University of Modena and Reggio Emilia in the last 7 years will be set up. Demographic,
clinical and biochemical data as well data regarding the reproductive history, time, type,
length of estrogen deprivation and of hormone-replacement therapy will be collected.