Mental Effects of Analgesic Drugs: Paracetamol and Ibuprofen
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
The objective of the present study is to study paracetamol effects on social pain and empathy
under standardized international conditions (ICH-GCP) for planning, conduction and reporting
of clinical pharmaceutical studies in humans. The study included MRI imaging of brain
activity, analysis of genomic biomarkers potentially explaining interindividual variation. It
is controversial whether the effects are of immediate nature or develop during a period of
about 10 days. Therefore, the study is separated into two study phases. Single dosing (SD) is
applied in study phase 1 and multiple-dosing (MD) in study phase 2. The study compares
paracetamol with placebo and in the study phase 1 also with ibuprofen as analgetically active
control.