Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
Participant gender:
Summary
Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney
disease (CKD) and large artery damage is a major factor that contributes to death. Metabolic
acidosis is a common complication of CKD resulting from an inability of the diseased kidney
to excrete the daily dietary acid load and it is associated with all-cause mortality in
patients with CKD. However, the effect of treatment of metabolic acidosis with oral sodium
bicarbonate on endothelial dysfunction and arterial stiffness in patients with CKD has not
been evaluated. The investigators propose a prospective, randomized, controlled, open-label
14-week crossover pilot study examining the effect of treatment of metabolic acidosis with
oral sodium bicarbonate on vascular endothelial function in 20 patients with CKD stage IV
with metabolic acidosis.