Metabolic Analysis in Human Sulfur Amino Acid Deficiency
Status:
Completed
Trial end date:
2007-02-01
Target enrollment:
Participant gender:
Summary
Varied food intake, disease, and genetic differences result in complex diet-health
interactions. In principle, information-rich metabolic analyses combined with bioinformatic
tools provide an approach to explore these interactions. This project is a feasibility study
of the use of high-resolution 1H-nuclear magnetic resonance (NMR) to study metabolic
perturbations induced by a deficiency in sulfur amino acids (SAA). The investigators will 1)
test the hypothesis that deficient dietary intake of SAA in humans results in oxidation of
reduced glutathione (GSH)/oxidized glutathione (GSSG) redox and 2) determine whether 1H-NMR
of blood and urine detects metabolic changes due to SAA deficiency.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)