Overview
Metabolic Effects of Chemical Interactions in Toxicity
Status:
Completed
Completed
Trial end date:
2007-11-01
2007-11-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
This pilot study tests the feasibility of using GSH redox state and high resolution proton NMR spectroscopy (1H-NMR) to detect metabolic changes due to acetominophen and sulfur amino acid deficiency. Our central hypothesis is that the a 2-day sulfur amino acid deficiency will alter acetominophen metabolism, acetominophen will affect sulfur amino acid homeostasis, and the treatments together will alter the global metabolic profile, as measured by 1H-NMR spectroscopy.Phase:
N/AAccepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Treatments:
Acetaminophen
Criteria
Inclusion Criteria:healthy volunteers males and females
Exclusion Criteria:
acute/chronic illnesses age less than 18 and greater than 40 pregnancy