Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea

• Status: Active, not recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in women with polycystic ovary syndrome (PCOS).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chicago
• Collaborator: Duke University
• Treatments: Estrogens; Leuprolide; Progesterone

Criteria

Inclusion Criteria:

• Clinical diagnosis of PCOS

• Obese (BMI of at least 30 kg/m2)

Exclusion Criteria:

• Diagnosis of nonclassic 21-hydroxylase deficiency, Cushing syndrome, hypothyroidism, or significant elevations in prolactin

• Taking steroid preparations (including oral contraceptives), medications known to alter insulin secretion and/or action, or medications known to influence sleep during the 2 months prior to starting the study

• Positive pregnancy test

• Diagnosis of diabetes mellitus

• Hypertension (systolic > 140 mmHg and/or diastolic > 90 mmhg) not well-controlled on stable medication with either ACE inhibitors or diuretics

• Habitual alcohol use

• Excessive caffeine intake of more than 300 mg/day

• Known peanut allergies, or allergies to medications used in the study

• Hemoglobin < 11g/dL and/or hematocrit < 33%

• Systemic illnesses, including heart, renal, liver, or malignant disease