One promising but understudied area in the field of testosterone (T) therapy is its effect on
metabolism and the development of type II diabetes. Metabolomics is a powerful research tool
that can detect very early signs of metabolic derangement that may lead to metabolic disease.
In this observational study, investigators aim to apply metabolomics in order to better
understand how T therapy influences metabolism. In a clinical population of outpatient men
with T deficiency investigators will perform comprehensive clinical evaluations and also
obtain blood for metabolomics. This will be done once prior to T therapy and again after 4-6
months of T therapy. Investigators hypothesize that they can detect metabolic derangements in
men with T deficiency and that these derangements will improve with T therapy.