Overview

Metabolomics of Intraoperative Saline and Balanced Crystalloid Infusion

Status:
Unknown status

Trial end date:
2021-02-01

Target enrollment:
0

Participant gender:
All

Summary

Different crystalloids, namely 0.9% saline and balanced crystalloid may result in different metabolomic profile among surgical patients. This study aims to investigate the serum and urine profiles between patients undergoing major spine surgery using 0.9% saline and balanced crystalloid.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

National Taiwan University Hospital

Criteria

Inclusion criteria:

1. age between 40 and 65 year-old

2. major lumbar spine surgery (spinal fusion、multiple levels or expected operation time>
2 hr)

Exclusion criteria:

1. Preoperative organ dysfunction, such as impaired liver function, eg. AST or ALT >100;
liver cirrhosis > Child B class; Impaired renal function, eGFR< 60 ml/min/1.73 m2;
cardiac dysfunction, such as heart failure > NYHA class II, coronary arterial disease

2. Preoperative use of medications which interfere with liver, renal or electrolyte
metabolism, such as statin or digoxin

3. Pregnancy