Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

• Status: Completed
• Trial end date: 2020-07-31
• Target enrollment: 0
• Participant gender: All

Summary

This pilot clinical trial studies how well metformin hydrochloride works in affecting cytokines and exosomes in patients with head and neck cancer. Metformin hydrochloride may reduce the metabolic activity of cancer cells and of surrounding supportive tissues.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Subjects with a diagnosis of head and neck cancer biopsy proven, and who are candidates for radiation therapy

• All subjects must be able to comprehend and sign a written informed consent document.

Exclusion Criteria:

• Subjects who are pregnant or may become pregnant during metformin administration; pregnancy testing will be done in conjunction with preradiation protocols

• Subjects on metformin for any reason during the preceding 4 weeks

• Diabetic subjects are eligible if they are not taking metformin or insulin

• Subjects who have received iodinated contrast dye must wait 12 hours prior to starting Metformin. If a CT scan with contrast is scheduled after screening and consent, the metformin cannot be taken until after the CT with contrast has been completed and they have waited 12 hours.

• Patients with plasma creatinine level greater than 1.3 mg/dL

• Patients with plasma bicarbonate less than 22 mEq/L or history of lactic or any other metabolic acidosis

• Patients with history of congestive heart failure

• Patients with myocardial ischemia or peripheral muscle ischemia

• Patients with sepsis or severe infection

• Patients with history of lung disease currently requiring any supplemental oxygen treatment

• Patients scheduled for radiation less than 6 days from enrollment

• Patients with history of hepatic dysfunction or hepatic disease and abnormal liver function tests; patients who have a history of hepatic dysfunction or hepatic disease and normal liver function tests will be eligible to participate

• Patients with a current history (in the past 30 days) of heaving drinking which is defined in accordance with CDC definition as more than 8 drinks per week for women and more than 15 drinks per week for men. A standard drink contains .6 ounces of pure alcohol. Generally, this amount of pure alcohol is found in 12-ounces of beer, 8-ounces of malt liquor, 5-ounces of wine, 1.5-ounces or a "shot" of 80-proof distilled spirits or liquor (e.g., gin, rum, vodka, or whiskey). While on study, patients should limit their alcohol consumption to no more than 8 drinks per week for women and no more than 15 drinks per week for men. Patients who feel they cannot comply with this recommendation are not eligible".

• All medications are permitted except those that are contraindicated with metformin under current Food and Drug Administration (FDA) recommendations