Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease
Status:
Terminated
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
The investigators are doing this research study to find out if taking Metformin improves
walking ability in patients with peripheral arterial disease (PAD). In PAD the arteries
(blood vessels) in the legs are narrowed because of the build up of plaque. The leg muscle
can hurt in patients with PAD and this is usually described as a cramp or tiredness. This
pain is called intermittent claudication. Metformin is an FDA approved medication for the
treatment of diabetes. The investigators believe that Metformin may help your leg muscles
work better.
The investigators will enroll up to 100 subjects in order to find 60 subjects with PAD at
Brigham and Women's Hospital (BWH).