Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer
Status:
Completed
Trial end date:
2018-08-01
Target enrollment:
Participant gender:
Summary
This phase II trial studies how well metformin hydrochloride, leucovorin calcium,
fluorouracil, and oxaliplatin work in treating patients with metastatic pancreatic cancer.
Metformin hydrochloride may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth. Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil,
and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing
the cells or by stopping them from dividing. Giving metformin hydrochloride together with
combination chemotherapy may kill more tumor cells