Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome
Status:
Completed
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
Phase III randomized controlled trial on men and women with Metabolic syndrome (MetS) to test
the hypothesis that comprehensive life-style changes and/or metformin treatment prevent
age-related chronic non-communicable diseases (ArCD).
The aim of the present study is to evaluate the effect of a comprehensive life-style
intervention (including moderate physical activity and Mediterranean/macrobiotic diet with
moderate calorie and protein restriction), and of treatment with Metformin (a calorie
restriction mimetic drug) for the prevention of ArCD.
Phase:
Phase 3
Details
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano