Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients
Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
Context: Metformin administration in women with polycystic ovary syndrome (PCOS) improves
hormonal and metabolic patterns with beneficial effects in terms of reproductive outcomes and
intermediate cardiovascular disease risk factors. Furthermore, reduced folate and vitamin
B12, and increased homocysteine (Hcy) levels have been found in type-2 diabetes mellitus
patients treated with metformin.
Objective: To evaluate if metformin administration exerts any effects on Hcy levels, and if
folate supplementation may improve endothelial structure and function in PCOS patients.