Metformin for the Treatment of Unexplained Oligozspermia

• Status: Unknown status
• Trial end date: 2017-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

Insulin resistance (IR) in men may be the underlying pathogenesis for metabolic abnormalities and chronic hypospermatogenesis similar to women with polycystic ovarian disease (PCOD). Infertile men with unexplained infertility and IR may benefit from treatment with metformin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Egyptian IVF-ET Center
• Treatments: Chorionic Gonadotropin; Citric Acid; Clomiphene; Enclomiphene; Metformin; Sodium Citrate; Zuclomiphene

Criteria

Inclusion Criteria:

• oligospermia ( < 10 million per mil-litter )

• normal FSH

• high insulin

Exclusion Criteria:

• abnormal karyotype

• obstructive azoospermia