Overview

Metformin in Children With Relapsed or Refractory Solid Tumors

Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the tolerability and safety of escalating doses of metformin on a backbone of vincristine, irinotecan and temozolomide (VIT) in children with recurrent and refractory solid tumors.
Phase:
Phase 1
Details
Lead Sponsor:
H. Lee Moffitt Cancer Center and Research Institute
Collaborator:
Pediatric Cancer Foundation
Treatments:
Camptothecin
Dacarbazine
Irinotecan
Metformin
Temozolomide
Vincristine