Metformin in Pregnant PCOS Women

• Status: Completed
• Trial end date: 2009-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

To investigate the effect of metformin on pregnancy complications and pregnancy outcome in the II. and III. trimester of pregnancy in women with polycystic ovary syndrome.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Norwegian University of Science and Technology
• Collaborator: St. Olavs Hospital
• Treatments: Metformin

Criteria

Inclusion Criteria:

• 18-45 years,

• PCOS diagnosis according to Rotterdam criteria

• single, viable, ultrasound verified fetus

• if metformin was used at conception and early pregnancy, at least 7 days of "wash out"

Exclusion Criteria:

• known liver disease or ALAT > 90 nmol/L

• known renal disease or creatinine > 110 micromol/L

• diabetes mellitus

• alcohol or drug abuse

• peroral steroid treatment

• cimetidine, anticoagulant or erythromycin treatment at time of inclusion

• not suitable for other reasons