Metformin to Prevent Metabolic Complications in Glucocorticoid Excess

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate if a treatment with metformin compared to placebo reduces metabolic side-effects in patients with glucocorticoid treatment over three months time.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Glucocorticoids; Metformin

Criteria

Inclusion Criteria:

• Glucocorticoid treatment for ≥ 3 months with a prednisone dose of ≥ 7.5mg/d or equivalent glucocorticoid

Exclusion Criteria:

• Refusal of informed consent

• Prior therapy with metformin during the last 6 month

• Preexisting diabetes

• Pregnancy or current malignancy

• Renal insufficiency with a creatinine clearance lower than 30ml/min