Overview

Metformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS Patients

Status:
Unknown status

Trial end date:
2020-12-31

Target enrollment:

Participant gender:

Summary

The purpose of this study was to determine whether metformin combined with exenatide once weekly (EQW) is more effective than metformin alone in the treatment of overweight/obese women with polycystic ovary syndrome (PCOS). Background therapies were Diane-35 or/and progesterone capsule. 80 participants were randomized to use either metformin or metformin+EQW for 12 weeks. Greater changes in body weight were anticipated in patients treated with EQW+metformin than metformin alone in those treated with metformin.

Phase:

Phase 4

Details

Lead Sponsor:

Peking Union Medical College Hospital

Treatments:

Exenatide
Glucagon
Glucagon-Like Peptide 1
Metformin