Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers

• Status: Unknown status
• Trial end date: 2020-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and beta-agonists using modified radioligand method.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Federal State Budgetary Institution, Pulmonology Scientific Research Institute
• Collaborators: Branch of Shemyakin-Ovchinnikov Institute of Bioorganic chemistry of RAS; Moscow State University of Medicine and Dentistry; National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
• Treatments: Bromides; Cholinergic Antagonists; Formoterol Fumarate; Methacholine Chloride; Tiotropium Bromide

Criteria

Inclusion Criteria:

1 Provision of signed and dated informed consent form 2. Healthy male or female, aged 18-60 years

Exclusion Criteria:

• Participants unable to perform spirometry

• Exacerbation respiratory infection within the previous four weeks

• Hypersensitivity or allergy to formoterol, metacholine or tiotropium bromide

• Females who are currently pregnant and lactating

• major surgery in the last 6 months

• Refusal to participate

• Currently participating in another clinical study