Methadone in Cystectomy Patients

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The role of a single-dose intraoperative methadone on postoperative pain and opioid consumption in patients undergoing Surgeon Accuracy Robot Assistant cystectomy. A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone in patients undergoing robotassisted cystectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Treatments: Methadone; Morphine

Criteria

Inclusion Criteria:

• All patients (≥18 years) scheduled for elective robot assisted cystectomy.

Exclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status IV or V

• Prolonged QTc-interval assessed by electrocardiogram (> 440 milliseconds)

• Existing treatment with a high risk of QTc-interval prolongation

• Allergy to study drugs

• Preoperative daily use of opioids

• Inability to provide informed consent

• Severe respiratory insufficiency (oxygen treatment at home)

• Heart failure (ejection fraction < 30%)

• Acute abdominal pain

• Signs of severe liver dysfunction (cirrhosis, inflammation/hepatitis or liver malignancy)

• Severe kidney insufficiency (estimated Glomerular Filtration Rate < 30 ml/min)

• Treatment with rifampicin

• Phaeochromocytoma

• Treatment with MAO-inhibitor during the last 14 days

• Pregnancy

• Nursing mothers

• Intraoperative conversion to open surgery (secondary inclusion criterion)

• Epidural analgesia in relation to surgical procedure