Overview

Methemoglobin Concentration in High Dose Inhaled Nitric Oxide

Status:
Not yet recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to learn about the kinetic of methemoglobin in healthy subjects breathing high dose inhaled nitric oxide. The main questions it aims to answer are: - What are the kinetics of methemoglobin formation at different concentrations of nitric oxide and oxygen - What are the kinetics of methemoglobin reduction after nitric oxide discontinuation Participants will be exposed to intermittent high dose inhaled nitric oxide while being continuously monitored.
Phase:
Early Phase 1
Details
Lead Sponsor:
Massachusetts General Hospital
Treatments:
Nitric Oxide