Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics

• Status: Completed
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

To establish and compare maximum methemoglobin blood levels and times to maximum methemoglobin blood levels following the administration of the injectable local anesthetics prilocaine and lidocaine when used for dental treatment in pediatric patients under general anesthesia. Patients will be randomized into three equal study groups. Two of the study groups will receive local anesthetic and the third group will not. Methemoglobin blood levels will be non-invasively monitored and recorded throughout dental treatment for all groups using a Masimo Radical-7 Pulse Co-Oximeter device.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Loma Linda University
• Treatments: Anesthetics; Anesthetics, Local; Epinephrine; Epinephryl borate; Lidocaine; Prilocaine; Racepinephrine

Criteria

Inclusion Criteria:

• Patient scheduled to undergo comprehensive dental treatment under general anesthesia at the Koppel Special Care Dentistry Center at Loma Linda University School of Dentistry

• ASA I or II health status

• Age greater than 3 years but less than 6 years

• Weigh between 10kg and 25kg

Exclusion Criteria:

• Patient not requiring restorative dental treatment

• Have a BMI less than the 5th percentile or greater than the 95th percentile for their age and gender