Method of Endogenous TSH Stimulation in the Follow-up of Differentiated Thyroid Cancer

• Status: Completed
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The treatment of differentiated thyroid cancer (DCT) includes surgery followed by radioiodine treatment. In the follow-up of patients it is necessary to induce TSH elevation to test for cancer recurrence. One of the options is to stop L-thyroxin replacement for several weeks. Current pilot study aims to induce the necessary TSH elevation by decreasing the L-thyroxin dose. The main hypothesis is that necessary TSH stimulation will be achieved during 4-6 weeks in majority of patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Tartu

Criteria

Inclusion Criteria:

• Differentiated thyroid cancer

• treated by thyroidectomy and at least 1 ablation with 131-I > 5 months ago

• TSH < 4 imU/L

Exclusion Criteria:

• Pregnancy

• Known metastasis