Methods to Reduce Blood Loss in Abdominal Myomectomy

• Status: Not yet recruiting
• Trial end date: 2022-09-15
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of the study is to compare the effectiveness of a single preoperative dose of vaginal misoprostol, intraoperative oxytocin infusion, IV carbetocin and pericervical tourniquet for the reduction of blood loss during of abdominal myomectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Carbetocin; Hemostatics; Misoprostol; Oxytocin

Criteria

Inclusion Criteria:

1. Age between 20-40 years.

2. 1-5 symptomatic intramural, submucous or subserous myomas by ultrasound

3. Mean uterine fibroid size of 5-10 cm

4. Presented with abnormal uterine bleeding, dull lower abdominal pain, infertility or recurrent miscarriage and are candidates for abdominal myomectomy.

Exclusion Criteria:

1. History of previous abdominal or pelvic surgery (laparotomy) except Cesarian section.

2. History of pelvic or ovarian endometriosis.

3. History of PID.

4. Patient with pedunculated subserous fibroid.

5. Patients who are candidate for laparoscopic or hysteroscopic myomectomy.

6. Allergy to misoprostol.

7. Hypertension, Diabetes Mellitus, Cardiac and pulmonary diseases.

8. Obesity BMI > 30 kg/m².

9. Anemia Hb < 10 g/dL.

10. Bleeding disorder or use of anticoagulation.

11. Preoperative use of hormonal therapy as GnRH analogues or oral contraceptive pills.

12. Pregnancy.

13. Postmenopausal.