Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic Leukemia

• Status: Terminated
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as methotrexate and fludarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.

PURPOSE: This phase II trial is studying how well methotrexate works as first-line therapy and fludarabine works as second-line therapy in treating patients with T-cell large granular lymphocytic leukemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: German CLL Study Group
• Treatments: Fludarabine; Fludarabine phosphate; Methotrexate; Vidarabine

Criteria

DISEASE CHARACTERISTICS:

• Confirmed diagnosis of T-cell large granular lymphocytic (T-LGL) leukemia

• Must have concurrent anemia or neutropenia

PATIENT CHARACTERISTICS:

• Life expectancy ≥ 2 years

• Not pregnant

• Fertile patients must use effective contraception

• No other malignancy

• No active infection

PRIOR CONCURRENT THERAPY:

• No prior immunosuppressive treatment

• No previous treatment with methotrexate or fludarabine