Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
This multicentre randomized placebo-controlled clinical trial aims to evaluate whether
methotrexate (MTX) has effects of relieving symptoms and reducing inflammation on advanced
knee osteoarthritis (OA) with inflammatory phenotype. Participants will be randomly allocated
to either MTX group or placebo group receiving MTX or placebo once a week. The primary
outcomes are effusion-synovitis volume measured by magnetic resonance imaging (MRI) and knee
pain assessed by visual analogue scale (VAS).
Phase:
N/A
Details
Lead Sponsor:
Zhujiang Hospital
Collaborators:
Beijing Hospital First Affiliated Hospital of Harbin Medical University Peking Union Medical College Hospital Peking University People's Hospital The First Affiliated Hospital of Anhui Medical University The Second People's Hospital of GuangDong Province Third Affiliated Hospital, Sun Yat-Sen University Xuanwu Hospital, Beijing