Methylnaltrexone Use for Opioid-induced Postoperative Constipation

• Status: Completed
• Trial end date: 2015-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the routine use of methylnaltrexone in the post-operative pediatric spinal fusion patient will decrease the incidence of constipation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shriners Hospitals for Children
• Treatments: Analgesics, Opioid; Bisacodyl; Bismuth subsalicylate; Magnesium Hydroxide; Methylnaltrexone; Naltrexone; Polyethylene glycol 3350

Criteria

Inclusion Criteria:

• spinal fusion surgery

• current opioid use

• 12 years of age and older

• no or inadequate bowel movement by post-operative day 3

Exclusion Criteria:

• known or expected mechanical bowel obstruction

• known or suspected lesions of the GI tract

• unexpected transfer to ICU

• unexpected return to the operating room

• patient or parent refusal of methylnaltrexone

• incomplete data concerning time to laxation