Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis
Status:
Unknown status
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
Diabetes mellitus (DM) is a widely prevalent disease associated with several major systemic
and oral complications, such as periodontitis. The use of adjunctive local and/or systemic
antimicrobials has been proposed to improve the clinical and glycemic outcomes of the scaling
and root planing (SRP) in diabetic subjects. The combination of metronidazole (MTZ) and
amoxicillin (AMX) has been largely recognized as an effective therapy for improving the
clinical and microbiological outcomes of SRP in the treatment of with chronic periodontitis
(ChP). However, no previous clinical trials to date have evaluated the effects of this
antibiotic combination in the treatment of diabetic subjects with periodontitis. Therefore,
the aim of this randomized clinical trial (RCT) will be to evaluate the clinical and
microbiological effects of the use of MTZ+AMX as adjuncts to SRP for the treatment of type 2
diabetic subjects with generalized ChP.