MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

It has been reported that volatile anesthetics preconditioning mediates protection of organ via microRNA. We want to study on the effects of isoflurane preconditioning on expression of microRNA and mRNA in the specimens of internal mammary artery and ascending aorta.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Liang Zhang
• Treatments: Anesthetics; Isoflurane; Propofol

Criteria

Inclusion Criteria:

• age >18 years

• written informed consent;

• scheduled procedures;

• planned isolated OPCABG(multiple bypass are allowed; planned combined intervention such as CABG plus valve surgery are not allowed);

• ejection fraction> 50%;

• NYHA class Ⅱ~Ⅲ;

• serum creatinine <150μmol / l;

• preoperative platelet content > 100 × 109 / l;

• preoperative hemoglobin> 120 g / l

Exclusion Criteria:

• pregnancy;

• planned valve surgery or surgery on the aorta;

• left main coronary artery stenosis> 75%;

• echocardiographic examination revealed moderate to severe mitral, tricuspid, or aortic regurgitation or stenosis;

• unstable or ongoing angina;

• recent (< 1 month) or ongoing acute myocardial infarction;

• use of sulfonylurea, theophylline or allopurinol;

• previous unusual response to an anesthetic agent;

• inclusion in other randomised controlled studies in the previous 30 days; (10)any general anesthesia performed in the previous 30 days;

• emergency operation (not scheduled);

• kidney or liver transplant in medical history, liver cirrhosis (Child B or C);

• chronic respiratory disease (such as chronic obstructive pulmonary emphysema)