Microbial Associations in Periodontal Health and Disease

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the clinical and microbiological effects of systemically administered metronidazole alone or in combination with professional plaque removal on periodontally diseased patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Forsyth Institute
• Collaborator: National Institute of Dental and Craniofacial Research (NIDCR)
• Treatments: Metronidazole

Criteria

Inclusion:

• > 35 years of age

• > 20 teeth

• > 5% sites (approx. 8 sites) with pocket depth > 4 mm and / or 5% sites with attachment level > 4 mm

Exclusion:

• > 50% of sites with pocket depth or attachment level > 4 mm

• Pregnancy or lactation

• Periodontal or antibiotic therapy in the previous 12 months

• Any systemic condition which might influence the course of periodontal disease or treatment (e.g. diabetes, AIDS)

• Any systemic condition which requires antibiotic coverage for routine periodontal procedures (e.g. heart conditions, joint replacements etc.)

• Any known allergy to metronidazole