Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke

• Status: Terminated
• Trial end date: 2006-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The study is designed to examine the safety, tolerability, and activity of a combination of microbubbles (perflutren lipid microsphere [Definity®]) and continuous monitoring with 2 MHz transcranial Doppler ultrasound (TCD) as an adjunctive therapy to tissue plasminogen activator (tPA) treatment in subjects with acute ischemic stroke.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: ImaRx Therapeutics

Criteria

Inclusion Criteria:

• Measurable focal neurological deficit (National Institutes of Health Stroke Scale [NIHSS] score > 4 points)

• tPA eligible

• Occlusion of the middle cerebral artery

Exclusion Criteria:

• Right to left cardiac shunt

• Uncontrolled hypertension

• Absent temporal windows