Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The optimal levels of mean arterial pressure that must be achieved in septic shock are subject of debate. Studies tried to correlate blood pressure increase in patients with septic shock with microcirculation. However, there are few studies that specifically assessed septic shock patients with previous arterial hypertension. The main objective of this study is to evaluate the effect of increased blood pressure level in the microcirculation of these patients and compare them with patients without arterial hypertension.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Treatments: Norepinephrine

Criteria

Inclusion Criteria:

• age over than 18 years old,

• norepinephrine drug use for at least 12 hours and for less than 72 hours,

• sedation level equal or deeper than Ramsay 4,

• blood pressure stable for the last 30 minutes prior to inclusion,

• central venous catheter in place and

• signed informed consent.

Exclusion Criteria:

• pregnancy,

• cirrhosis,

• systemic sclerosis, and

• need to maintain mean arterial pressure above 65mmHg for others conditions