Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical Centre Leeuwarden
• Collaborator: Lithuanian University of Health Sciences
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

• severe sepsis and septic shock

Exclusion Criteria:

• pregnancy

• oral bleeding

• age < 18 years

• liver cirrhosis

• acute arrhythmias

• advanced malignancy or a mean arterial pressure (MAP) < 65 mmHg refractory to vasopressors