Lumbar puncture is one of the most common painful procedures performed on neonates in the
Emergency Department (ED). The investigators will study in a randomized controlled trial, the
efficacy of intravenous administration of a single dose of Midazolam in reducing pain and
anxiety in neonates undergoing lumbar puncture in the ED, as well as the rate of adverse
sedation reactions. The investigators hypothesize that compared with placebo, single dose
Midazolam would significantly decrease pain and anxiety and will have low rate of adverse
reactions.