Midazolam Versus Dexamethasone-ondansetron in Preventing Postoperative Nausea-vomiting for Laparoscopic Surgeries
Status:
Completed
Trial end date:
2019-11-15
Target enrollment:
Participant gender:
Summary
Postoperative nausea and vomiting(PONV) affects 11 to 60 % of patients undergoing surgery and
is a major cause of postoperative morbidity. Risk factors include female gender, non smokers,
postoperative use of opioids and a past history of PONV. The simplified Apfel risk score is
used to identify patients at risk for PONV. PONV prophylaxis is provided intraoperatively to
patients with 2 or more risk factors. In spite of numerous drugs available, control of PONV
remains a difficult task. Midazolam is a commonly used drug perioperatively for its
anxiolytic and sedative properties. It decreases analgesic requirement and has also been
found to have an antiemetic effect. This present study is designed to compare the
prophylactic use of iv midazolam with a commonly used combination of
dexamethasone-ondansetron in high risk patients (as defined by the modified Apfel score)
undergoing laparoscopic surgeries.