Midodrine Versus Albumin for Prevention of Paracentesis Induced Circulatory Disturbance
Status:
Recruiting
Trial end date:
2022-03-20
Target enrollment:
Participant gender:
Summary
Paracentesis-induced circulatory disturbance (PICD) is a very common cause of mortality and
morbidity in patients undergoing large-volume paracentesis. Albumin is commonly used in
decompensated cirrhosis during large-volume paracentesis. However, it may not be
cost-effective and has side effects like volume overload and transfusion reactions.
Therefore the investigator proposed to use midodrine which is a drug that increases the mean
arterial pressure. The investigators hypothesized that midodrine may be effective in
preventing PICD in acute on chronic liver failure patients requiring modest paracentesis.
This has already been found to be effective in initial studies in decompensated cirrhosis