Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
Status:
Recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
Vasopressors are medications that are given intravenously to increase the blood pressure of
patients with illnesses that cause dangerous blood pressure drops. When a doctor prescribes a
vasopressor, they ask that the dose be adjusted to achieve a specific blood pressure. This
kind of medical support with intravenous (IV) vasopressors are usual treatments in intensive
care unit (ICU) settings. Oral vasopressors, such as midodrine, have been historically used
to maintain blood pressure in non-critically ill patients. In this study, the investigators
will be using midodrine to reduce the need for IV vasopressors as blood pressure improves
during the stay in the ICU.
The LIBERATE multi-site study will continue the work of the pilot study to evaluate the role
of midodrine for patients with low blood pressure in the ICU.
Phase:
Phase 4
Details
Lead Sponsor:
University of Alberta
Collaborators:
Alberta Health Services Institute of Health Economics, Canada University Hospital Foundation