Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2

• Status: Unknown status
• Trial end date: 2007-09-01
• Target enrollment: 0
• Participant gender: All

Summary

We hypothesised that intravenous infusion of PGI2 induced headache or migraine and cranial vasodilatation in migraineurs.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Glostrup University Hospital, Copenhagen
• Treatments: Epoprostenol; Tezosentan

Criteria

Inclusion Criteria:

• migraine without aura and healthy apart from that

• age 18-55 years

• 50-100 kg

• Secure contraceptives

Exclusion Criteria:

• Tension Type Headache more than 3 time a month

• Other primary headaches

• Medication prior to the study (closer than 4 times plasma halflife)

• Migraine or headache 5 days prior to study.

• Hypertension (systolic BP >150 mmHg and/or diastolic BP >100 mmHg).

• Hypotension (systolic BP <90 mmHg and/or diastolic BP <50 mmHg).

• Heart-vessel disease of any kind incl cerebrovascular disease.

• Anamnestic or clinical signs of psychiatric disease or abuse.

• Anamnestic or clinical signs of disease of any kind relevant for participation in the study.