Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin

• Status: Completed
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose that post-exercise milk protein feeding will enhance the mitochondrial protein synthesis (biogenesis) response to an exercise-training program. In addition, the investigators propose that this stimulatory effect of protein feeding will overcome the potential blunting effect of metformin on exercise responses. The investigators will investigate these outcomes over a 12-week exercise-training program in older adults with pre-diabetes with or without metformin treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colorado State University
• Treatments: Metformin

Criteria

Inclusion Criteria:

• 55 years or older

• Individuals with Prediabetes defined as impaired fasting glucose (100 to 126 mg/dl), HbA1c (5.7-6.4%), and/or impaired glucose tolerance defined as 2 hour postprandial blood glucose of 140 to 200 mg/dl.

Exclusion Criteria:

• Medications contraindicated with Metformin (Dofetilide, Lamotrigine, Pegvisomant, Somatropin, Trimethoprim, Trospium, Gatifloxacin, Cephalexin, Cimetidine, Dalfampridine)

• Recent (less than 6 weeks) or planned imaging that requires IV contrast,

• Renal dysfunction creatinine ≥ 1.3 mg/dL in men or ≥ 1.2 mg/dL in women

• Alanine Aminotransferase (ALT) levels exceed 52 IU/L

• Heart, Kidney or Liver Disease

• Type I or Type II Diabetes

• Anti-coagulant therapy (warfarin/heparin)

• Lung/respiratory dysfunction

• Medications affecting primary outcomes

• Lactose Intolerant

• Tobacco Use

• Heavy Alcohol Use

• Cancer

• Lidocaine Allergy