Mind and Body Approaches to Pain Reduction in Youth With Migraine
Status:
Recruiting
Trial end date:
2023-06-02
Target enrollment:
Participant gender:
Summary
The overarching objective of this protocol is to identify and understand the neural and pain
processing mechanisms by which youth with migraine improve in response to preventive
treatment. The study design of this mechanistic investigation includes functional magnetic
resonance imaging (fMRI), daily headache diaries, assessment of conditioned pain modulation
via quantitative sensory testing, and validated psychometric assessments before and after the
delivery of one of five treatments over an 8 week period [cognitive behavioral therapy (CBT),
biofeedback-assisted relaxation training (BART) and cognitive reappraisal (CR) training,
amitriptyline, and placebo]. We are examining both distinct and common pathways that may help
explain the response to various preventive treatments, as well as potential predictors of
outcome.
Phase:
Phase 2
Details
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Collaborators:
National Center for Complementary and Integrative Health (NCCIH) National Institute of Neurological Disorders and Stroke (NINDS)
Treatments:
Amitriptyline Amitriptyline, perphenazine drug combination