Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram

• Status: Completed
• Trial end date: 2012-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Sevoflurane can abolish movement or adrenergic response to noxious stimulus. In order to investigate the effect of sevoflurane on cerebral electrical activity, we determined the MAC of sevoflurane inducing isoelectric electroencephalogram (EEG) in 50% of the subjects (MACie) in middle aged subjects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Huazhong University of Science and Technology
• Collaborators: Ministry of Health, China; National Natural Science Foundation of China
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• 45-65yr

• upper abdominal surgery in general anaesthesia

• ASA physical status classification of I or II

Exclusion Criteria:

• neurological disease

• received central nervous system-active drugs

• cardiac ejection fraction less than 40%

• history of difficult intubation or anticipated difficult intubation

• daily alcohol consumption

• obesity, defined as a body-mass index of more than 30

• without informed consent