Minimum Alveolar Concentration of Sevoflurane With Nitrous Oxide Inducing Isoelectric EEG

• Status: Completed
• Trial end date: 2013-10-01
• Target enrollment: 0
• Participant gender: All

Summary

In order to investigate the effect of a combination effect of sevoflurane and nitrous oxide on cerebral electrical activity, the investigators determined the MAC of sevoflurane combined with nitrous oxide inducing isoelectric electroencephalogram (EEG) in 50% of the subjects (MACie) in middle aged subjects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Huazhong University of Science and Technology
• Treatments: Nitrous Oxide; Sevoflurane

Criteria

Inclusion Criteria:

• between 45 to 64 years old

• ASA physical status class 1 or 2

• elective abdominal surgery

• Informed Consent

Exclusion Criteria:

• history of neurological disease

• received central nervous system-active drugs

• cardiac ejection fraction less than 40%

• history of difficult intubation or anticipated difficult intubation

• daily alcohol consumption

• obesity, defined as a body-mass index of more than 30

• without informed consent

• others judged inappropriate as subjects for the study by the Study Chair