Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged
patients. POCD and POD may increase the mortality and morbidity. However, the mechanism of
POCD is not clear yet and no effective therapy method was proved. According to previous
study, the neuroinflammation is the main reason both for POCD and POD. Minocycline is a
tetracycline derivative. Due to it's lipophilic structure, it is easy to pass through blood
brain barrier and attenuate neuroinflammation. It's neuroprotective effects has been proven
in many experimental animal models such as Alzheimer's disease, Huntington's disease and
Parkinson's syndrome. In present study, the investigators hypothesized that minocycline would
attenuate the incidence of POCD and POD in the aged patients.
Phase:
Phase 3
Details
Lead Sponsor:
RenJi Hospital
Collaborators:
Pudong New Area People's Hospital Shanghai 10th People's Hospital Shanghai Pudong Hospital Shanghai Pudong New Aera Dongming Community Health Care Center Shnaghai Tenth People's Hospital