Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the safety and efficacy of a drug minocycline in improving outcomes at 3 months after rupture of an aneurysm in the head.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University at Buffalo
• Collaborator: University at Buffalo Neurosurgery
• Treatments: Minocycline

Criteria

Inclusion Criteria:

• ≥ 18 yrs of age

• Ruptured aneurysm

• Initiate treatment within 72 hours of SAH

• Pre Rankin ≤ 1

Exclusion Criteria:

• Hunt & Hess 5 with no improvement

• ICP > 30

• No plans to treat aneurysm

• Allergy to Tetracycline / Antibiotics

• Creatinine >2

• Platelets < 75,000

• Other brain diseases

• Previous infection requiring Tetracycline