Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting

• Status: Recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: All

Summary

Mirtazapine is a noradrenergic and specific serotonergic antidepressant. Its antagonist at the 5HT3 receptor may help to prevent nausea and vomiting. The use of mirtazapine in the management of nausea and vomiting has been reported in the literature, both for treatment and premedication.

Dexamethasone, possesses analgesic, anti-inflammatory, immune-modulating, and antiemetic effects. Dexamethasone was reported to be effective in preventing nausea and vomiting in patients receiving cancer chemotherapy. It has also been shown to be effective in reducing nausea and vomiting after open and laparoscopic surgical procedures.

In this randomized controlled trial, we will compare the effectiveness of both drugs in preventing PONV in laparoscopic cholecystectomy surgery.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Dexamethasone; Mirtazapine

Criteria

Inclusion Criteria:

• ASA physical status I or II

• body weight 60-100 Kg

• scheduled for laparoscopic cholecystectomy under general anaesthesia

Exclusion Criteria:

• Patient's refusal to participate in the study,

• Obesity with body mass index (BMI) >35 kg/m2,

• Physical status: ASA III or above,

• Patients with a history of PONV, motion sickness, or major systemic diseases

• Patients who received an antiemetic drug within 48 h before surgery,

• Patients facing liver or kidney problems with a high level of BUN or serum creatinine,

• A history of allergy to the study drugs.

• Pregnant, lactating, or menstruating patients