Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester Abortion

• Status: Completed
• Trial end date: 2017-12-15
• Target enrollment: 0
• Participant gender: Female

Summary

the investigators aimed to study the efficacy and safety of nitric oxide donors when combined with prostaglandins in induction of second trimester abortion expecting that both drugs when used together will be of greater efficiency and associated with less side effects.

the study included 60 women with gestational age between 13weeks+0day and 26weeks+6days indicated for pregnancy termination due to maternal or fetal cause.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Isosorbide; Isosorbide Dinitrate; Isosorbide-5-mononitrate; Misoprostol

Criteria

Inclusion Criteria:

• Age 16 -40 years

• Missed abortion

• Singelton pregnancy

• Gestationl age between 13 and 26 weeks of pregnancy

• Normal uterus and cevix on clinical examination

• Cervix is not dilatated

• No uterine activity and vaginal bleeding

• Written and informed consent by the patient

• Unscarred uterus

Exclusion Criteria:

• Presence of uterine contraction or bleeding

• Evidences suggesting of onset of spontaneous abortion as Previous trial to induce abortion

• Multifetal pregnancy

• Suspicion of septic abortion

• History of cervical surgery or manipulation

• Uterine anomaly

• IUD in situ

• Associtaed hemorrhagic disorder

• History of adverse effects to vaginally adminstered medication

• Inability to insert vaginal medication high in vagina