Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions

• Status: Recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to specifically investigate whether oxytocin and mechanical dilation decreases the rate of cesarean section compared to misoprostol and mechanical dilation for pregnancies at risk of fetal compromise

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thomas Jefferson University
• Treatments: Misoprostol; Oxytocin

Criteria

Inclusion Criteria:

• • Age > 18 years old

• Singleton, or twins with demise of one

• Cephalic presentation

• Intact membranes

• Hypertension (chronic hypertension, gestational hypertension, pre-eclampsia with/without severe features, superimposed preeclampsia with/without severe features, eclampsia, HELLP)

• Oligohydramnios (AFI< 5cm and/or MVP <2cm)

• Fetal growth restriction (EFW or AC <10th percentile) with normal or abnormal (elevated, absent, or reversed) Umbilical Artery Dopplers

• Abnormal antenatal fetal testing (NST, Biophysical profile, decreased fetal movement) prompting induction of labor

• Suspected placental abruption

• Poorly controlled pre-gestational diabetes, defined as >50% abnormal glucose values requiring increasing doses of anti-glycemic agents >34 weeks, or requiring delivery

• Gestational Age > 22 weeks

• Bishop score < 6

Exclusion Criteria:

• • Prior cesarean delivery

• Allergy to misoprostol

• Allergy to oxytocin

• Allergy to silicone/latex

• Contraindication to vaginal delivery including placenta or vasa previa, Placenta accreta/increta/percreta, prior uterine rupture, Prior myomectomy entering the uterine cavity and necessitating cesarean delivery, active genital herpes, transverse or oblique fetal lie, umbilical cord prolapse, or HIV viral load >1000 copies/mL