Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate
Status:
Withdrawn
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Major burn injury causes significant insulin resistance on glucose and protein metabolism
that persists for up to 6 months after the acute injury
This project proposes to answer the following questions:
1. Will fenofibrate given to burn patients with insulin resistance restore their insulin
sensitivity?
2. What is the relationship between mitochondrial dysfunction in muscle tissue as the
causative mechanism of burn related insulin resistance?
3. To what extent will the restored insulin sensitivity affect glucose and protein
metabolism in muscle, regenerating wounds and the liver, i.e. ameliorate burn related
hyperglycemia and protein catabolism?