Mitoxantrone and Prednisone With or Without Leflunomide in Treating Patients With Stage IV Prostate Cancer
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Combining more than one drug may kill more tumor cells. It is not
yet known if mitoxantrone and prednisone are more effective with or without leflunomide for
treating prostate cancer.
PURPOSE: Randomized phase II/III trial to compare the effectiveness of mitoxantrone and
prednisone with or without leflunomide in treating patients who have stage IV prostate cancer
that has not responded to hormone therapy.