Model-informed Precision Dosing of Vancomycin in Adults

• Status: Recruiting
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The overall objective of this project is to investigate the utility of model-informed precision dosing (MIPD) of vancomycin in non-critically ill adults. This evaluation includes a comparison with the more standard approach on clinical and patient-oriented measures.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Ghent
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

• 18 years or older

• admitted to a participating ward unit

• a suspected or confirmed Gram positive infection

• planned to start of started on intravenous continuous infusion vancomycin treatment

• participant or legal representative signed the informed consent form

• not previously enrolled in this trial

Exclusion Criteria:

• serum creatinine level at inclusion is above 2.5 mg/dL

• undergoing extracorporeal treatment at inclusion (e.g. extracorporeal membrane oxygenation, dialysis, body cooling)

• patient death is deemed imminent and inevitable.